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Abstract

Formulation and Evaluation of Fast Dissolving Tablet of Levocetrizine using Direct Compression Technique

Ajay Kaurav1, Prince Jain1, Subhendu S. Mishra2*, Ritesh Verma2

1. Bhabha College of Pharmacy, Bhopal, M.P, India.

2. Sapience Bioanalytical Research Laboratory, Bhopal, M.P, India.

ABSTRACT

In this investigation fast dissolving tablets of Levocetrizine Hcl were prepared using different super disintegrants by direct compression method. Fast dissolving tablets prepared by direct compression and using super disintegrants like Croscarmellose sodium and crospovidone in different concentration and evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation F6 containing super disintegrant crospovidone was considered to be best formulation, which release up to 98.89% in 5 min.

Keywords: Levocetrizine HCl; Mouth dissolving tablet; super disintegrants; Dissolution rate.


[Full Text Article]